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Angew Chem Int Ed Engl. 2009;48(17):3099-103. doi: 10.1002/anie.200806244.

Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology.

Author information

1
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.

Abstract

Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology.

PMID:
19308940
DOI:
10.1002/anie.200806244
[Indexed for MEDLINE]

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