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Acta Obstet Gynecol Scand. 2009;88(6):629-34. doi: 10.1080/00016340902846098.

Concentrations of vascular endothelial growth factor C and D in amniotic fluid and maternal plasma.

Author information

1
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Biomedicum Helsinki, Finland. katja-anneli.wathen@helsinki.fi

Abstract

OBJECTIVE:

Vascular endothelial growth factor-C (VEGF-C) and VEGF-D promote both endothelial and lymphatic vascularization during embryonic development. We studied their presence in amniotic fluid (AF) and maternal plasma during pregnancy.

DESIGN:

Descriptive study. Setting. University Central Hospital, Helsinki, Finland. Samples. AF at 14-20 weeks (n=20) and 38-41 weeks' of gestation (n=20), serial plasma samples (n=38) from 16 healthy pregnant women during 8-40 weeks of pregnancy, and plasma from 15 non-pregnant controls.

METHODS:

Enzyme-linked immunosorbent assay (ELISA). Main outcome measures. Concentrations of VEGF-C and -D in AF and maternal plasma.

RESULTS:

VEGF-C concentrations in AF decrease as pregnancy advances (p=0.002) and are about 10-fold lower than in plasma at the corresponding gestational age (p=0.001). Plasma VEGF-C concentrations are higher in the first trimester (p=0.014) and the early second trimester (p=0.016) than in non-pregnant women. VEGF-D is not detectable in AF, but in plasma its concentrations become higher at term compared with non-pregnant women (p=0.039).

CONCLUSIONS:

VEGF-C and -D are present in high concentrations in maternal plasma, while only VEGF-C can be detected in AF.

PMID:
19308753
DOI:
10.1080/00016340902846098
[Indexed for MEDLINE]
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