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J Child Orthop. 2008 Dec;2(6):491-5. doi: 10.1007/s11832-008-0128-7. Epub 2008 Sep 30.

Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model.

Author information

1
Laboratoire d'Antibiologie Clinique et Expérimentale UPRES EA 3826, Faculté de Médecine, Université de Nantes, Nantes, France, antoine.hamel@chu-nantes.fr.

Abstract

PURPOSE:

This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model.

METHODS:

Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated.

RESULTS:

Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score.

CONCLUSION:

Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis.

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