Format

Send to

Choose Destination
See comment in PubMed Commons below
J Gerontol A Biol Sci Med Sci. 2009 May;64(5):516-21. doi: 10.1093/gerona/glp024. Epub 2009 Mar 20.

Insulin sensitivity as a key mediator of growth hormone actions on longevity.

Author information

1
Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA. mmasternak@siumed.edu

Abstract

Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df) and growth hormone receptor knockout [GHRKO]) and normal mice, insulin sensitivity was strongly associated with longevity. Of particular interest was enhancement of the already increased insulin sensitivity in CR df/df mice in which longevity was also further extended and the lack of changes in insulin sensitivity in calorically restricted GHRKO mice in which there was no further increase in average life span. We suggest that enhanced insulin sensitivity, in conjunction with reduced insulin levels, may represent an important (although almost certainly not exclusive) mechanism of increased longevity in hypopituitary, growth hormone (GH)-resistant, and calorie-restricted animals. We also report that the effects of GH treatment on insulin sensitivity may be limited to the period of GH administration.

PMID:
19304940
PMCID:
PMC2667133
DOI:
10.1093/gerona/glp024
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center