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Phytomedicine. 2009 Sep;16(9):887-90. doi: 10.1016/j.phymed.2009.02.015. Epub 2009 Mar 20.

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.

Author information

1
Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.

Abstract

Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.

PMID:
19303753
DOI:
10.1016/j.phymed.2009.02.015
[Indexed for MEDLINE]

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