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Arzneimittelforschung. 1991 Jun;41(6):660-3.

Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man.

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Department of Medical Biophysics, Institut de Biologie, Montpellier, France.


An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal in order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique. The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.

[Indexed for MEDLINE]

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