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Thromb Res. 2009;123 Suppl 4:S72-8. doi: 10.1016/S0049-3848(09)70148-3.

Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes.

Author information

1
Department of Surgery, University of Michigan, USA. henke@umich.edu

Abstract

Chronic venous insufficiency resulting in post-thrombotic syndrome occurs commonly after acute deep vein thrombosis, and is a prevalent cause of vascular disease morbidity in the community. Therefore, a better understanding of the pathophysiologic mechanisms that promote the development of chronic venous insufficiency could lead to novel approaches to interrupt the natural history and prevent post-thrombotic syndrome. In this paper, we will review the evidence that venous thrombus resolution is an inflammatory process that is dependent on chemokines and leukocytes.

PMID:
19303509
DOI:
10.1016/S0049-3848(09)70148-3
[Indexed for MEDLINE]

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