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Bioorg Med Chem Lett. 2009 Apr 15;19(8):2354-9. doi: 10.1016/j.bmcl.2008.09.066. Epub 2008 Sep 20.

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.

Author information

1
Department of Medicine, Columbia University, New York, NY 10032, USA.

Abstract

Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.

PMID:
19303288
PMCID:
PMC2738751
DOI:
10.1016/j.bmcl.2008.09.066
[Indexed for MEDLINE]
Free PMC Article

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