Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Surg Oncol. 2009 Oct;35(10):1060-4. doi: 10.1016/j.ejso.2009.02.011. Epub 2009 Mar 19.

Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer.

Author information

1
Department of Surgery, Kantonsspital Sankt Gallen, Rorschacherstrasse 95, 9007 Sankt Gallen, Switzerland. francesco.marra@kssg.ch

Abstract

AIMS:

Long-term outcome for curative colon cancer surgery may be impaired by anastomotic leakage, but most studies regard colon and rectal cancer patients as one group. The aim of this study was to determine whether anastomotic leakage following potentially curative resection for colon cancer is a risk factor for postoperative mortality and for long-term survival.

PATIENTS AND METHODS:

Medical records of a cohort of 440 consecutive patients undergoing 445 curative resections for explicit colon cancer with primary anastomosis above the peritoneal reflection were reviewed. Therefore patients with rectal cancer were not included. Diagnosis of leakage was made by clinical features or abdominal CT-scans.

RESULTS:

The study population consisted of 266 men and the mean age was 68.6 years. Median follow-up time was 66.5 months. Anastomotic leakage occurred in 12 patients. Four of these died within 30 days after surgery compared to 15 of the remaining 428 patients without leakage (p<0.001). The 5-year overall survival rate was 25% in patients with anastomotic leakage compared to 61.2% in those without leakage (p<0.001). Excluding 30-day mortality, respective values were 33.3 and 63.7% (p=0.02).

CONCLUSION:

Although anastomotic failure after colon cancer surgery is rare, it is a very severe complication that not only impairs the perioperative morbidity and mortality but also significantly influences the long-term outcome negatively.

PMID:
19303243
DOI:
10.1016/j.ejso.2009.02.011
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center