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J Reprod Med. 2009 Feb;54(2):47-52.

Preterm birth prevention by 17 alpha-hydroxyprogesterone caproate vs. daily nursing surveillance.

Author information

1
Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

OBJECTIVE:

To compare the incidence of spontaneous recurrent preterm delivery (SPTD) between women receiving 17 alpha-hydroxyprogesterone caproate (17P) and women receiving daily perinatal nursing surveillance (dPNS) with home uterine activity monitoring.

STUDY DESIGN:

Women enrolled for dPNS or weekly nursing visits with 17P injection were eligible. Included were singletons with previous SPTD, without preterm labor (PTL), cerclage or vaginal bleeding and < 27 weeks at enrollment. 17P and dPNS patients were matched 1:1 by race, marital status, tobacco use and number of SPTDs. Primary study outcome was incidence of spontaneous PTD.

RESULTS:

Data from 342 matched pairs were compared. Diagnosis of PTL (39.2% vs. 60.8%) and tocolytic use (12.9% vs. 49.7%) was decreased with 17P vs. dPNS (p < 0.001). The incidences of spontaneous PTD at < 32, 35 and 37 weeks were similar between the groups.

CONCLUSION:

There was no difference in recurrent SPTD between women treated with 17P and those receiving dPNS.

PMID:
19301566
[Indexed for MEDLINE]

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