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Anat Rec (Hoboken). 2009 Apr;292(4):557-61. doi: 10.1002/ar.20872.

Rotation of organizer tissue contributes to left-right asymmetry.

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1
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

Abstract

Current hypotheses regarding vertebrate left-right asymmetry patterns are based on the presumption that genetic regulatory networks specify sidedness via extracellular morphogens and/or ciliary activity. We show empirical time-lapse evidence for an asymmetric rotation of epiblastic nodal tissue in avian embryos. This rotation spans the interval when initial symmetric expression of Shh and Fgf8 becomes asymmetrical with respect to the midline.

PMID:
19301278
PMCID:
PMC2714534
DOI:
10.1002/ar.20872
[Indexed for MEDLINE]
Free PMC Article
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