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Biotechnol Prog. 2009 Mar-Apr;25(2):530-4. doi: 10.1002/btpr.130.

Plant-produced human growth hormone shows biological activity in a rat model.

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Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA.


Plants have been shown to be efficient systems for expressing a wide range of recombinant proteins from various origins. Here, using a plant virus-based expression vector to produce human growth hormone (hGH) in Nicotiana benthamiana plants, we demonstrate, for the first time, that the plant-produced hGH (pphGH) is biologically active in a hypophysectomized rat model. We observed an average weight gain of approximately 17 g per animal in a group of 10 animals that were injected subcutaneously with pphGH with 60 microg/dose for 10 days. With the increasing demand for hGH, accompanied with the need to make this recombinant protein available to a wider population at a more reasonable cost, plants provide a feasible alternative to current production platforms.

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