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Neuropsychiatr Dis Treat. 2007 Dec;3(6):705-9.

Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD).

Author information

1
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. cledwa00@acpub.duke.edu

Abstract

Traditionally, neuropsychological deficits due to Sickle Cell Disease (SCD) have been understudied in adults. We have begun to suspect, however, that symptomatic and asymptomatic Cerebrovascular Events (CVE) may account for an alarming number of deficits in this population. In the current brief review, we critically evaluated the pediatric and adult literatures on the neurocognitive effects of SCD. We highlighted the studies that have been published on this topic and posit that early detection of CVE via neurocognitive testing, neuropsychiatric evaluations, and neuroimaging may significantly reduce adult cognitive and functional morbidities.

KEYWORDS:

cerebral vascular event; neuroimaging; neuropsychological assessment; sickle cell disease

PMID:
19300604
PMCID:
PMC2656311

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