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Nat Rev Drug Discov. 2009 Apr;8(4):297-307. doi: 10.1038/nrd2356. Epub 2009 Mar 20.

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules.

Author information

1
Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Biological barriers regulate the passage of cells, pathogens, fluids, nutrients, ions and signalling molecules between anatomical compartments during homeostasis and disease. Yet strategies that allow for reversible therapeutic modulation of these barriers are still in their infancy. The enhancement or protection of natural barriers is desirable in conditions such as acute respiratory distress syndrome or ischaemia-reperfusion injuries, whereas a temporary disruption could facilitate the penetration of drugs across such barriers. This Review discusses the role of sphingosine-1-phosphate receptors in the regulation and protection of biological barriers, and the potential of therapeutic strategies that target this receptor family.

PMID:
19300460
PMCID:
PMC4455967
DOI:
10.1038/nrd2356
[Indexed for MEDLINE]
Free PMC Article

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