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Nat Rev Neurosci. 2009 Apr;10(4):262-71. doi: 10.1038/nrn2594.

Transient cell-cell interactions in neural circuit formation.

Author information

1
Neurosciences Program, Stanford University, Stanford, CA 94305, USA.

Abstract

The wiring of the nervous system requires a complex orchestration of developmental events. Emerging evidence suggests that transient cell-cell interactions often serve as positional cues for axon guidance and synaptogenesis during the assembly of neural circuits. In contrast to the relatively stable cellular interactions between synaptic partners in mature circuits, these transient interactions involve cells that are not destined to be pre- or postsynaptic cells. Here we review the roles of these transient cell-cell interactions in a variety of developmental contexts and describe the mechanisms through which they organize neural connections.

PMID:
19300445
PMCID:
PMC3083859
DOI:
10.1038/nrn2594
[Indexed for MEDLINE]
Free PMC Article

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