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Bioorg Med Chem Lett. 2009 Apr 15;19(8):2252-7. doi: 10.1016/j.bmcl.2009.02.093. Epub 2009 Feb 27.

Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.

Author information

1
Division of Medicinal Chemistry, Faculty of Sciences, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands.

Abstract

A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.

PMID:
19299127
DOI:
10.1016/j.bmcl.2009.02.093
[Indexed for MEDLINE]

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