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Semin Immunol. 2009 Apr;21(2):84-91. doi: 10.1016/j.smim.2009.02.003.

Biochemical signaling pathways for memory T cell recall.

Author information

1
Department of Surgery, University of Maryland School of Medicine, MSTF Building, Room 400, 685 W. Baltimore Street, Baltimore, MD 21201, United States. dfarber@smail.umaryland.edu

Abstract

Memory T cells exhibit low activation thresholds and rapid effector responses following antigen stimulation, contrasting naive T cells with high activation thresholds and no effector responses. Signaling mechanisms for the distinct properties of naive and memory T cells remain poorly understood. Here, I will discuss new results on signal transduction in naive and memory T cells that suggest proximal control of activation threshold and a distinct biochemical pathway to rapid recall. The signaling and transcriptional pathways controlling immediate effector function in memory T cells closely resemble pathways for rapid effector cytokine production in innate immune cells, suggesting memory T cells use innate pathways for efficacious responses.

PMID:
19298946
PMCID:
PMC2683752
DOI:
10.1016/j.smim.2009.02.003
[Indexed for MEDLINE]
Free PMC Article
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