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Clin Chim Acta. 2009 May;403(1-2):223-5. doi: 10.1016/j.cca.2009.03.016. Epub 2009 Mar 17.

The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus.

Author information

1
Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, PR China.

Abstract

BACKGROUND:

Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE).

METHODS:

One hundred thirty-eight SLE patients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay.

RESULTS:

In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455).

CONCLUSIONS:

The IL-16 gene polymorphisms may be associated with the risk of SLE.

PMID:
19298795
DOI:
10.1016/j.cca.2009.03.016
[Indexed for MEDLINE]

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