Send to

Choose Destination
Dev Growth Differ. 2009 Apr;51(3):233-40. doi: 10.1111/j.1440-169X.2009.01092.x. Epub 2009 Feb 27.

Roles of planar cell polarity pathway genes for neural migration and differentiation.

Author information

Center for Transdisciplinary Research, Niigata University, Niigata, Japan.


Planar cell polarity (PCP) in epithelial cells is essential for the organization of tissues and their functions. The conserved non-canonical Wnt/PCP pathway regulates this process in both Drosophila and vertebrates. However, recent studies have revealed that a similar set of genes, which may not be related to PCP, regulates oriented cell movement during development. In the present review, recent findings on neural migration in zebrafish hindbrain and axonal guidance in mouse forebrain and spinal cord are discussed. Future analyses on defects in vertebrate PCP mutants will provide novel insights into the conserved and diverse roles of non-canonical Wnt/PCP pathway genes in vertebrate brain development.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center