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Exp Physiol. 2009 May;94(5):509-19. doi: 10.1113/expphysiol.2008.043984. Epub 2009 Mar 18.

The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches.

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1
Department of Physiology & Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK. clive.orchard@bristol.ac.uk

Abstract

The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions. While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation-contraction coupling.

PMID:
19297389
DOI:
10.1113/expphysiol.2008.043984
[Indexed for MEDLINE]
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