Send to

Choose Destination
See comment in PubMed Commons below
Exp Physiol. 2009 May;94(5):509-19. doi: 10.1113/expphysiol.2008.043984. Epub 2009 Mar 18.

The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches.

Author information

Department of Physiology & Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK.


The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions. While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation-contraction coupling.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center