Send to

Choose Destination
J Phys Chem A. 2009 Mar 26;113(12):2943-52. doi: 10.1021/jp8100859.

Homonuclear versus heteronuclear resonance-assisted hydrogen bonds: tautomerism, aromaticity, and intramolecular hydrogen bonding in heterocyclic systems with different exocyclic proton donor/acceptor.

Author information

STC Institute for Single Crystals, National Academy of Sciences of Ukraine, 60 Lenina Avenue, Kharkiv 61001, Ukraine.


Tautomerism and resonance-assisted hydrogen bonding have been analyzed on the basis of the results of ab initio calculations at the MP2/AUG-cc-pVDZ level of theory for the series of molecules containing different heterocycles connected with resonance spacer and containing different exocyclic proton donor/acceptor atoms. It is demonstrated that the position of tautomeric equilibrium is controlled mainly by two factors: aromaticity of heterocycle, which could be different for two tautomers, and relative proton affinities of two heteroatoms forming a hydrogen bond. Replacement of exocyclic proton donor/acceptor atom results in change of an aromaticity degree of heterocycle leading to alteration of relative stability of tautomers. Comparison of structure and properties of E and Z conformers of molecules demonstrates resonance-assisted character of intramolecular hydrogen bond. Application of the NBO theory reveals that the pi-component of the electron density within resonant spacer plays the primary role for determination of characteristics of hydrogen bond while sigma-skeleton only reflects the pi-polarization. An analysis of strength of intramolecular hydrogen bond using geometrical, energetic, and AIM and NBO parameters indicates that the homonuclear N...H-N hydrogen bond is considerably weaker than heteronuclear N...H-O and N...H-S hydrogen bonds in the case of the XH tautomers.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center