Format

Send to

Choose Destination
Small. 2009 Jul;5(13):1562-8. doi: 10.1002/smll.200900186.

Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide.

Author information

1
Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA. yhoshino@uci.edu

Abstract

Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.

PMID:
19296557
PMCID:
PMC2804256
DOI:
10.1002/smll.200900186
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center