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J Child Neurol. 2009 Aug;24(8):1008-9. doi: 10.1177/0883073809332700. Epub 2009 Mar 18.

Childhood mefloquine-induced mania and psychosis: a case report.

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Department of Pediatrics, The Institute of Child Health, Kolkata, West Bengal, India.


Mefloquine, a commonly used oral antimalarial is occasionally associated with severe, neuropsychiatric adverse effects, especially in adults. Such events are extremely rare in children. The authors report on an 11-year-old, otherwise healthy girl from Eastern India, a malaria-endemic region, who developed mania and psychosis following intake of a therapeutic dose of mefloquine for Plasmodium falciparum malaria. She recovered satisfactorily with risperidone therapy. To our knowledge, there is only one documented instance of mefloquine-induced psychosis in the pediatric literature to date. Those caring for children need to realize that severe neuropsychiatric manifestations may be seen in the pediatric age group. A positive history of intake of the offending drug with careful exclusion of other etiologies usually clinches the diagnosis.

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