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Rev Med Chir Soc Med Nat Iasi. 2008 Apr-Jun;112(2):321-6.

[Alcoholic ketoacidosis].

[Article in Romanian]

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Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicină, Centrul Clinic de Diabet, Nutriţie si Boli Metabolice.


Alcoholic ketoacidosis is an acute metabolic acidosis that typically occurs in people who chronically abuse alcohol and have a recent history of binge drinking, little or no food intake and persistent vomiting. Alcoholic ketoacidosis is a result of starvation with glycogen depletion and counter-regulatory hormone production, a raised nicotinamide adenine dinucleotide (NADH) to nicotinamide adenine dinucleotide (NAD+) ratio related to the metabolism of ethanol, and volume depletion resulting in ketogenesis. Alcoholic ketoacidosis is characterized by elevated serum ketone levels and a high anion gap. Once the diagnosis of alcoholic ketoacidosis is made, the mainstay of treatment is hydration with 5% dextrose in normal saline. With timely and aggressive intervention, the prognosis for a patient with alcoholic ketoacidosis is good.

[Indexed for MEDLINE]

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