Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2009;48(29):5309-12. doi: 10.1002/anie.200900064.

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.

Author information

1
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

Abstract

Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

PMID:
19294716
DOI:
10.1002/anie.200900064
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center