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Antimicrob Agents Chemother. 1991 Jul;35(7):1486-8.

Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method.

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1
Institute of General Pathology, Catholic University, Rome, Italy.

Abstract

A simple, sensitive, and reproducible assay for the measurement of the amphotericin B concentration in tissue extracts was developed by using the fourth derivative of the absorption spectrum of amphotericin B between wavelengths of 330 and 430 nm. The amphotericin B concentration in spleen and brain was proportional to the total amount administered. The amphotericin B concentration in the brain was highly correlated with the increase in the mean incubation period of intracerebrally scrapie-infected hamsters.

PMID:
1929313
PMCID:
PMC245196
[Indexed for MEDLINE]
Free PMC Article
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