Abstract
The present study investigated whether combination of resveratrol and 4-amino 1,8 naphthalimide (4-ANI) is effective in the development of diabetic neuropathy (DN). After 6 weeks of diabetes induction, rats were treated for 2 weeks with resveratrol and 4-amino 1,8 naphthalimide (4-ANI) either alone or in combination. Experimental end points included functional, behavioural and biochemical parameters along with PAR immunohistochemistry and were performed at the end of treatment. Combination of resveratrol (10 mg/kg) and 4-ANI (3 mg/kg) attenuated conduction and nerve blood flow deficits and resulted in amelioration of diabetic neuropathic pain. Significant reversal of biochemical alterations (peroxynitrite, MDA and NAD levels) were also observed, as well as PAR accumulation in the sciatic nerve. This study suggests the beneficial effect of combining resveratrol and 4-ANI in experimental diabetic neuropathy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Naphthylamine / administration & dosage
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1-Naphthylamine / analogs & derivatives*
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Animals
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Antioxidants / administration & dosage
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Diabetic Neuropathies / drug therapy*
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Diabetic Neuropathies / physiopathology
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Male
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Malondialdehyde / metabolism
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NAD / metabolism
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Naphthalimides / administration & dosage*
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Neural Conduction / drug effects
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Neuralgia / drug therapy
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Neuroprotective Agents / administration & dosage*
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Oxidative Stress / drug effects
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Pain Measurement
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Peroxynitrous Acid / metabolism
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Poly Adenosine Diphosphate Ribose / metabolism
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Quinolones / administration & dosage*
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Rats
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Rats, Sprague-Dawley
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Resveratrol
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Sciatic Nerve / drug effects
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Sciatic Nerve / physiopathology
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Stilbenes / administration & dosage*
Substances
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Antioxidants
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Naphthalimides
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Neuroprotective Agents
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Quinolones
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Stilbenes
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NAD
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Peroxynitrous Acid
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4-amino-1,8-naphthalimide
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Poly Adenosine Diphosphate Ribose
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Malondialdehyde
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1-Naphthylamine
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Resveratrol