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Arch Dermatol. 2009 Mar;145(3):273-6. doi: 10.1001/archdermatol.2008.591.

Successful treatment of complex aphthosis with colchicine and dapsone.

Author information

1
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Abstract

OBJECTIVE:

To investigate the effectiveness of colchicine and dapsone, 2 corticosteroid-sparing anti-inflammatory agents, in the treatment of patients with complex aphthosis (recurrent oral and genital aphthous ulcers or severe, almost constant, multiple oral aphthae in the absence of Beh├žet syndrome).

DESIGN:

Retrospective review of medical records.

SETTING:

Tertiary care medical clinic.

PATIENTS:

Fifty-five patients with complex aphthosis evaluated and treated at Mayo Clinic between January 1, 1998, and July 31, 2007. All the patients were treated according to a therapeutic ladder, starting with colchicine and adding dapsone to treatment of patients who did not have a substantial response (>75% improvement) to colchicine or who discontinued colchicine use because of adverse effects.

MAIN OUTCOME MEASURES:

A substantial response to therapy with colchicine alone, dapsone alone, or colchicine and dapsone combined.

RESULTS:

Most patients (44 [80%]) had a substantial response to therapy and had no serious adverse effects.

CONCLUSIONS:

Colchicine and dapsone are effective, safe therapies for the treatment of complex aphthosis. Colchicine and dapsone, 2 established drugs also used for gout and leprosy, respectively, and for other dermatologic disorders, should be considered efficacious in the treatment of complex aphthosis.

PMID:
19289756
DOI:
10.1001/archdermatol.2008.591
[Indexed for MEDLINE]

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