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Antimicrob Agents Chemother. 2009 May;53(5):2136-8. doi: 10.1128/AAC.01506-08. Epub 2009 Mar 16.

In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.

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1
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

Abstract

In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.

PMID:
19289531
PMCID:
PMC2681559
DOI:
10.1128/AAC.01506-08
[Indexed for MEDLINE]
Free PMC Article
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