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Antimicrob Agents Chemother. 2009 Jun;53(6):2636-7. doi: 10.1128/AAC.01415-08. Epub 2009 Mar 16.

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains.

Author information

1
LA Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, RB-2, Rm 230, Torrance, CA 90502, USA. sjyang@labiomed.org

Abstract

We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.

PMID:
19289517
PMCID:
PMC2687189
DOI:
10.1128/AAC.01415-08
[Indexed for MEDLINE]
Free PMC Article

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