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Dev Cell. 2009 Mar;16(3):323-4. doi: 10.1016/j.devcel.2009.03.002.

Sphingosine-1 phosphate: a new player in osteoimmunology.

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1
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA. brendan_boyce@urmc.rochester.edu

Abstract

Osteoclasts, the cells that degrade bone, differentiate from bone marrow-derived myeloid precursors. Recent work by Ishii et al. shows that sphingosine-1 phosphate in blood attracts osteoclast precursors into the bloodstream to keep them away from bone surfaces. These findings point to a novel mechanism to inhibit bone degradation and prevent bone loss.

PMID:
19289077
DOI:
10.1016/j.devcel.2009.03.002
[Indexed for MEDLINE]
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