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Dev Cell. 2009 Mar;16(3):321-2. doi: 10.1016/j.devcel.2009.02.015.

Harness the power: new insights into the inhibition of YAP/Yorkie.

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  • 1Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0815, USA.

Abstract

YAP/Yorkie (Yki) is a transcriptional coactivator that controls organ size; dysregulation causes tumorigenesis by stimulating cell proliferation and inhibiting apoptosis. The Hippo pathway restrains YAP/Yki activity, but it remains unclear how cellular regulation at the plasma membrane influences the Hippo-YAP/Yki pathway. Two papers in this issue on Developmental Cell, by Badouel et al. and Nishioka et al., address this question.

PMID:
19289076
DOI:
10.1016/j.devcel.2009.02.015
[PubMed - indexed for MEDLINE]
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