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Nat Genet. 2009 Apr;41(4):396-8. doi: 10.1038/ng.321. Epub 2009 Mar 15.

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.

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1
Hubrecht Institute-KNAW & University Medical Centre, Utrecht, The Netherlands.

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

PMID:
19287381
DOI:
10.1038/ng.321
[Indexed for MEDLINE]
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