Format

Send to

Choose Destination
Cell Adh Migr. 2009 Apr-Jun;3(2):179-81. Epub 2009 Apr 30.

Integrin switching modulates adhesion dynamics and cell migration.

Author information

1
Leiden Amsterdam Center for Drug Research, Leiden University, Netherlands.

Abstract

When cells are stimulated to move, for instance during development, wound healing or angiogenesis, they undergo changes in the turnover of their cell-matrix adhesions. This is often accompanied by alterations in the expression profile of integrins-the extracellular matrix receptors that mediate anchorage within these adhesions. Here, we discuss how a shift in expression between two different types of integrins that bind fibronectin can have dramatic consequences for cell-matrix adhesion dynamics and cell motility.

PMID:
19287215
PMCID:
PMC2679881
DOI:
10.4161/cam.3.2.8036
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center