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Trends Plant Sci. 2009 Apr;14(4):206-13. doi: 10.1016/j.tplants.2009.01.003. Epub 2009 Mar 13.

Thinking outside the F-box: novel ligands for novel receptors.

Author information

1
Department of Plant Cellular and Molecular Biology, The Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA. somers.24@osu.edu

Abstract

The importance of regulated proteolysis in the physiology and development of plants is highlighted by the large number of genes dedicated to proteasome-dependent protein degradation. Within the SCF class of E3 ubiquitin ligases are more than 700 F-box proteins that act as recognition modules to specifically target their dedicated substrates for ubiquitylation. This review focuses on very recent studies indicating that some F-box proteins function as phytohormone or light receptors, which directly perceive signals and facilitate specific target-protein degradation to regulate downstream pathways. If this new connection between ligand-regulated proteolysis and signaling proves to be more extensive, an entirely new way of understanding the control of signal transduction is in the offing.

PMID:
19285909
DOI:
10.1016/j.tplants.2009.01.003
[Indexed for MEDLINE]

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