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Trends Plant Sci. 2009 Apr;14(4):206-13. doi: 10.1016/j.tplants.2009.01.003. Epub 2009 Mar 13.

Thinking outside the F-box: novel ligands for novel receptors.

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Department of Plant Cellular and Molecular Biology, The Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA.


The importance of regulated proteolysis in the physiology and development of plants is highlighted by the large number of genes dedicated to proteasome-dependent protein degradation. Within the SCF class of E3 ubiquitin ligases are more than 700 F-box proteins that act as recognition modules to specifically target their dedicated substrates for ubiquitylation. This review focuses on very recent studies indicating that some F-box proteins function as phytohormone or light receptors, which directly perceive signals and facilitate specific target-protein degradation to regulate downstream pathways. If this new connection between ligand-regulated proteolysis and signaling proves to be more extensive, an entirely new way of understanding the control of signal transduction is in the offing.

[Indexed for MEDLINE]

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