Format

Send to

Choose Destination
Biochim Biophys Acta. 2009 Dec;1796(2):140-61. doi: 10.1016/j.bbcan.2009.03.001. Epub 2009 Mar 12.

Cancer gene discovery in mouse and man.

Author information

1
Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.

Abstract

The elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire cancer genomes. In parallel with these advances mouse models of cancer have evolved into a powerful tool for cancer gene discovery. Here we discuss the approaches that may be used for cancer gene identification in both human and mouse and discuss how a cross-species 'oncogenomics' approach to cancer gene discovery represents a powerful strategy for finding genes that drive tumourigenesis.

PMID:
19285540
PMCID:
PMC2756404
DOI:
10.1016/j.bbcan.2009.03.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center