Format

Send to

Choose Destination
Pulm Pharmacol Ther. 2009 Apr;22(2):75-81. doi: 10.1016/j.pupt.2009.01.003. Epub 2009 Jan 20.

Central regulation of the cough reflex: therapeutic implications.

Author information

1
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA. bjc@jhmi.edu

Abstract

In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been found to be relatively safe and effective antitussives. Similarly, now in five different species (guinea pigs, rabbits, cats, dogs and pigs), neurokinin receptor antagonists have also proven to be safe and effective antitussive agents. Both of these classes of drugs act centrally to prevent cough. A brief review of what is known about the central encoding of cough is presented, as are the advantages of centrally acting antitussives. Also discussed are new insights into cough and NMDA receptor signaling that may lead to the development of more effective antitussive agents with limited side effects and broad application in treating cough associated with a variety of aetiologies.

PMID:
19284972
PMCID:
PMC2695989
DOI:
10.1016/j.pupt.2009.01.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center