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ACS Nano. 2009 Apr 28;3(4):1004-10. doi: 10.1021/nn900113x.

Label-free DNA sensor based on surface charge modulated ionic conductance.

Author information

  • 1Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003, USA.

Abstract

The surface charge effect in controlling ionic conductance through a nanoporous alumina membrane is investigated for its application in a convenient detection method of unlabeled DNA. To this goal, surface modification with mixtures of neutral silanes and morpholinos (neutral analogues of DNA) was optimized to yield a strong effect on ionic conductance change upon DNA binding, which can exceed an order of magnitude. The effect can be employed in fabrication of inexpensive DNA sensors.

PMID:
19284734
PMCID:
PMC2729444
DOI:
10.1021/nn900113x
[PubMed - indexed for MEDLINE]
Free PMC Article
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