Format

Send to

Choose Destination
See comment in PubMed Commons below
Genome Biol. 2009;10(3):R28. doi: 10.1186/gb-2009-10-3-r28. Epub 2009 Mar 10.

Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes.

Author information

1
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse, Neuherberg, Germany. g.kastenmueller@helmholtz-muenchen.de

Abstract

Identifying the biochemical basis of microbial phenotypes is a main objective of comparative genomics. Here we present a novel method using multivariate machine learning techniques for comparing automatically derived metabolic reconstructions of sequenced genomes on a large scale. Applying our method to 266 genomes directly led to testable hypotheses such as the link between the potential of microorganisms to cause periodontal disease and their ability to degrade histidine, a link also supported by clinical studies.

PMID:
19284550
PMCID:
PMC2690999
DOI:
10.1186/gb-2009-10-3-r28
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center