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Am J Sports Med. 2009 Jun;37(6):1135-42. doi: 10.1177/0363546508330974. Epub 2009 Mar 12.

Use of autologous platelet-rich plasma to treat muscle strain injuries.

Author information

1
Union Memorial Hospital, Department of Orthopedic Surgery, Baltimore, Maryland, USA.

Abstract

BACKGROUND:

Standard nonoperative therapy for acute muscle strains usually involves short-term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery.

HYPOTHESIS:

Local delivery of platelet-rich plasma to injured muscles hastens recovery of function.

STUDY DESIGN:

Controlled laboratory study.

METHODS:

In vivo, the tibialis anterior muscles of anesthetized Sprague-Dawley rats were injured by a single (large strain) lengthening contraction or multiple (small strain) lengthening contractions, both of which resulted in a significant injury. The tibialis anterior either was injected with platelet-rich plasma, was injected with platelet-poor plasma as a sham treatment, or received no treatment.

RESULTS:

Both injury protocols yielded a similar loss of force. The platelet-rich plasma only had a beneficial effect at 1 time point after the single contraction injury protocol. However, platelet-rich plasma had a beneficial effect at 2 time points after the multiple contraction injury protocol and resulted in a faster recovery time to full contractile function. The sham injections had no effect compared with no treatment.

CONCLUSION:

Local delivery of platelet-rich plasma can shorten recovery time after a muscle strain injury in a small-animal model. Recovery of muscle from the high-repetition protocol has already been shown to require myogenesis, whereas recovery from a single strain does not. This difference in mechanism of recovery may explain why platelet-rich plasma was more effective in the high-repetition protocol, because platelet-rich plasma is rich in growth factors that can stimulate myogenesis.

CLINICAL RELEVANCE:

Because autologous blood products are safe, platelet-rich plasma may be a useful product in clinical treatment of muscle injuries.

PMID:
19282509
PMCID:
PMC3523111
DOI:
10.1177/0363546508330974
[Indexed for MEDLINE]
Free PMC Article

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