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Trends Biochem Sci. 2009 Apr;34(4):158-61. doi: 10.1016/j.tibs.2008.12.006. Epub 2009 Mar 11.

H2A.Z and DNA methylation: irreconcilable differences.

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Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28(th) Avenue, Vancouver, BC V5Z 4H4, Canada.


DNA methylation state and the composition of the nucleosome core particle influence chromatin structure and, in turn, transcriptional competence. Although it is clear that chromatin remodeling and covalent histone modifications regulate DNA methylation in plants and animals, the role of histone variants in directing DNA methylation, and vice versa, has not been addressed. A new genome-wide study in Arabidopsis thaliana reveals a broadly antagonistic relationship between H2A.Z occupancy and DNA methylation.

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