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Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. doi: 10.1016/j.bmcl.2009.02.077. Epub 2009 Feb 25.

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.

Erratum in

  • Bioorg Med Chem Lett. 2011 Sep 15;21(18):5647-8.

Abstract

New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.

PMID:
19282171
DOI:
10.1016/j.bmcl.2009.02.077
[Indexed for MEDLINE]

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