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Am J Med. 1991 Sep 30;91(3C):2S-13S.

Oxidants and antioxidants: state of the art.

Author information

1
Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands.

Abstract

Reactive oxygen species are regarded as merely pernicious. This is incorrect for they play a pivotal role in many physiologic reactions, such as cytochrome P450-mediated oxidations, regulation of the tone of smooth muscle, and killing of microorganisms. An imbalance in oxidant-antioxidant activity is involved in many free radical-mediated pathologies, e.g., ischemia-reperfusion and asthma. In an attempt to alleviate these pathologies with antioxidants, it should be noted that these compounds are neither specific nor mere antioxidants. Associated with antioxidant activity is a pro-oxidant action. In the development of new antioxidant therapies, the important question of how these drugs are incorporated in or commensurate with existing integrated physiologic radical-defense systems should be addressed.

PMID:
1928207
[Indexed for MEDLINE]

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