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Int J Cardiol. 2010 Oct 8;144(2):304-6. doi: 10.1016/j.ijcard.2009.02.029. Epub 2009 Mar 17.

Association between the use of non-antiarrhythmic drugs and postoperative atrial fibrillation.

Abstract

PURPOSE:

To evaluate the association between statins, N-acetylcysteine (NAC) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and postoperative atrial fibrillation (AF).

METHODS:

A total of 590 patients undergoing coronary artery bypass and/or valve surgery were studied. An AF episode lasting >5 min during hospitalization was accepted as endpoint.

RESULTS:

AF rate was 18% (n=106). Multivariable positive predictors of AF included age ≥ 65, left atrial diameter ≥ 45 mm, cross clamp time; negative predictors included use of left internal mammarian artery, NAC, and ACEIs or ARBs.

CONCLUSIONS:

ACEIs or ARBs and NAC is associated with low incidence of postoperative AF, however, this association was not found with statin or combined use these agents.

PMID:
19282043
DOI:
10.1016/j.ijcard.2009.02.029
[Indexed for MEDLINE]
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