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FEMS Immunol Med Microbiol. 2009 Mar;55(2):271-9. doi: 10.1111/j.1574-695X.2008.00517.x.

A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge.

Author information

1
Department of Biology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, 78249, USA.

Abstract

Mice deficient in B cells (micromT mice) were used to evaluate the role of antibody in enhanced chlamydial clearance and reduction of pathology afforded by vaccination with recombinant chlamydial protease-like activity factor (rCPAF). Enhanced, but comparable, chlamydial clearance was observed in micromT and wild-type (WT) mice after rCPAF+CpG vaccination. Chlamydia-induced pathology was present in mock-immunized animals, but at significantly greater levels in micromT than WT mice, whereas vaccinated micromT and WT mice exhibited similar reductions in pathology. Thus, antibodies may play a role in protection against chlamydial pathology after primary infection, but were largely dispensable in rCPAF+CpG-induced chlamydial clearance and reduction in pathology.

PMID:
19281569
PMCID:
PMC4372721
DOI:
10.1111/j.1574-695X.2008.00517.x
[Indexed for MEDLINE]
Free PMC Article

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