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Organogenesis. 2008 Apr;4(2):100-8.

Wnt signaling in lung organogenesis.

Author information

1
Department of Pediatrics; National Jewish Medical Research Center; Denver, Colorado USA.

Abstract

Reporter transgene, knockout, and misexpression studies support the notion that Wnt/beta-catenin signaling regulates aspects of branching morphogenesis, regional specialization of the epithelium and mesenchyme, and establishment of progenitor cell pools. As demonstrated for other foregut endoderm-derived organs, beta-catenin and the Wnt/beta-catenin signaling pathway contribute to control of cellular proliferation, differentiation and migration. However, the contribution of Wnt/beta-catenin signaling to these processes is shaped by other signals impinging on target tissues. In this review, we will concentrate on roles for Wnt/beta-catenin in respiratory system development, including segregation of the conducting airway and alveolar compartments, specialization of the mesenchyme, and establishment of tracheal asymmetries and tracheal glands.

KEYWORDS:

airway; alveolar; endoderm; mesenchyme; morphogenesis; respiratory

PMID:
19279721
PMCID:
PMC2634255
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