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Brief Funct Genomic Proteomic. 2009 Jan;8(1):60-7. doi: 10.1093/bfgp/elp002. Epub 2009 Mar 11.

The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing.

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  • 1Gene Regulation Program, Centre de Regulació Genòmica, Dr Aiguader 88, Barcelona, Spain.


Removal of introns during pre-mRNA splicing is a critical process in gene expression, and understanding its control at both single-gene and genomic levels is one of the great challenges in Biology. Splicing takes place in a dynamic, large ribonucleoprotein complex known as the spliceosome. Combining Genetics and Biochemistry, Saccharomyces cerevisiae provides insights into its mechanisms, including its regulation by RNA-protein interactions. Recent genome-wide analyses indicate that regulated splicing is broad and biologically relevant even in organisms with a relatively simple intronic structure, such as yeast. Furthermore, the possibility of coordination in splicing regulation at genomic level is becoming clear in this model organism. This should provide a valuable system to approach the complex problem of the role of regulated splicing in genomic expression.

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