Format

Send to

Choose Destination
Immunology. 2009 Apr;126(4):458-65. doi: 10.1111/j.1365-2567.2008.03027.x.

CD56bright natural killer (NK) cells: an important NK cell subset.

Author information

1
Laboratoire d'Immunogénétique-Allergologie, Centre de Recherche Public de la Santé, Luxembourg-City, Luxembourg.

Abstract

Human natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56(bright) CD16(dim/) (-) and CD56(dim) CD16(+), respectively. In this review, we will focus on the CD56(bright) NK cell subset. These cells are numerically in the minority in peripheral blood but constitute the majority of NK cells in secondary lymphoid tissues. They are abundant cytokine producers but are only weakly cytotoxic before activation. Recent data suggest that under certain conditions, they have immunoregulatory properties, and that they are probably immediate precursors of CD56(dim) NK cells. CD56(bright) NK cell percentages are expanded or reduced in a certain number of diseases, but the significance of these variations is not yet clear.

PMID:
19278419
PMCID:
PMC2673358
DOI:
10.1111/j.1365-2567.2008.03027.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center