Format

Send to

Choose Destination
Pediatr Cardiol. 2009 Jul;30(5):617-25. doi: 10.1007/s00246-009-9391-8. Epub 2009 Mar 10.

Epicardial control of myocardial proliferation and morphogenesis.

Author information

1
Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St., IGM240, Los Angeles, CA 90033, USA. sucov@usc.edu

Abstract

The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.

PMID:
19277768
DOI:
10.1007/s00246-009-9391-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center