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Eur J Cardiovasc Prev Rehabil. 2009 Apr;16(2):161-3. doi: 10.1097/HJR.0b013e328320ad1b.

High dose of red wine elicits enhanced inhibition of fibrinolysis.

Author information

1
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. tuoski@utu.fi

Abstract

BACKGROUND AND DESIGN:

The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis.

METHODS:

Twenty-two healthy men consumed a high dose (8.1+/-0.9 dl) of alcohol-containing red wine and dealcoholized red wine, and an equal ethanol dose of cognac (2.4+/-0.3 dl). Blood samples were taken before and shortly after interventions.

RESULTS:

Red wine, unlike dealcoholized red wine and cognac, increased tissue plasminogen activator inhibitor-1 levels significantly, indicating an acute inhibition of fibrinolysis after a high dose.

CONCLUSION:

Findings may explain the increased risk of cardiovascular mortality among binge drinkers.

Comment in

PMID:
19276983
DOI:
10.1097/HJR.0b013e328320ad1b
[Indexed for MEDLINE]

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